Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury.

Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury.

Model: Single traumatic brain injury

G-1 significantly reduced hippocampal CA1 neuronal loss and improved cognitive impairment after traumatic brain injury, effects attenuated by LY294002, while tau hyperphosphorylation was not observed or altered.

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