THERAPY DOSSIER · th-a05b9815ed2f

G-1, a selective G-protein coupled estrogen receptor 1 agonist

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27908726 ↗2016Reported benefit

Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury.

RatTBIUnspecifiedSprague-Dawley (from MeSH indexing)Male (from MeSH indexing)

Model: Single traumatic brain injury

G-1 significantly reduced hippocampal CA1 neuronal loss and improved cognitive impairment after traumatic brain injury, effects attenuated by LY294002, while tau hyperphosphorylation was not observed or altered.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

Loading the evidence…