Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.
RatTBIWeight-drop / impact-accelerationSprague-Dawley (Taconic)Malen = 128 male rats in total, 6 to 8 per group, with 5 animals ex…IntraperitonealAnti-CGRP antibody and isotype control IgG 30 mg/kg in 0.54…Antibody first administered immediately after injury induction; sumatriptan giv…
Model: Mild closed head injury concussion by weight drop, with a 250 g weight dropped through a tube from 80 cm onto the centre of the head under 3% isoflurane with the animal chest-down on a foam sponge
Concussion produced cephalic tactile hypersensitivity, sumatriptan-conditioned place preference and prolonged glyceryl trinitrate hypersensitivity, all attenuated by acute sumatriptan and chronic anti-CGRP antibody, although the antibody had no effect on extracephalic hindpaw hypersensitivity.
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