Intraspinal microstimulation and diaphragm activation after cervical spinal cord injury.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleIntraspinal electrodes implanted in the ventral cervical spinal cord targeting the phrenic motor nucleus250 ms train stimulus at 100 Hz, 100 to 200 microampereAcute (hours after C2 hemisection) and subacute (5 to 21 days after injury)
Model: C2 lateral hemisection (C2Hx) of the cervical spinal cord, studied acutely (hours) and subacutely (5 to 21 days)
Genioglossus EMG activity effectively triggered intraspinal microstimulation and activated diaphragm motor units during inspiration after both acute and subacute C2 hemisection. Short-term potentiation of spontaneous inspiratory activity in the previously paralysed hemidiaphragm occurred in about 7…
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