THERAPY DOSSIER · th-338b791c9e5a

Intraspinal microstimulation via implanted electrodes, triggered by genioglossus inspiratory EMG activity

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27881723 ↗2016Reported benefit

Intraspinal microstimulation and diaphragm activation after cervical spinal cord injury.

RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleIntraspinal electrodes implanted in the ventral cervical spinal cord targeting the phrenic motor nucleus250 ms train stimulus at 100 Hz, 100 to 200 microampereAcute (hours after C2 hemisection) and subacute (5 to 21 days after injury)

Model: C2 lateral hemisection (C2Hx) of the cervical spinal cord, studied acutely (hours) and subacutely (5 to 21 days)

Genioglossus EMG activity effectively triggered intraspinal microstimulation and activated diaphragm motor units during inspiration after both acute and subacute C2 hemisection. Short-term potentiation of spontaneous inspiratory activity in the previously paralysed hemidiaphragm occurred in about 7…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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