Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation.
RatChemical/toxinWistarn = 84 rats across 6 groupsCurcumin 100 mg/kg/day; mercuric chloride 0.6, 1.2 and 2.4…Pretreatment before mercuric chloride exposure
Model: Mercuric chloride induced acute hepatotoxicity
Mercuric chloride caused dose-dependent hepatotoxicity with raised oxidative stress and apoptosis markers and activation of Nrf2 signalling. Curcumin pretreatment markedly prevented mercuric chloride induced hepatic oxidative stress, attributed to radical scavenging or induction of the Nrf2 antioxi…
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