Effect of PPAR-beta/delta agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/610 minutes before reperfusion
Model: Middle cerebral artery occlusion, 1 h of ischaemia followed by reperfusion
GW0742 given 10 minutes before reperfusion reduced infarct volume and oedema, blunted the hepatic acute phase response and neutrophil recruitment, and reduced blood-brain barrier leakage with upregulated tight junction proteins.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.