Evidence & regulatory context
- Mechanism
- ChEMBL returns the compound record but NO mechanism rows (get_mechanism returned zero), so no target is asserted here. Flagged in ChEMBL as a chemical probe (chemical_probe=1) with max_phase NULL, i.e. preclinical only.
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL record
- CHEMBL38508 ↗
- ChEMBL max phase
- Not recorded
- Synonyms
- GW0742; GW 0742; GW0742X; GW610742; CHEMBL38508
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/610 minutes before reperfusion
Model: Middle cerebral artery occlusion, 1 h of ischaemia followed by reperfusion
GW0742 given 10 minutes before reperfusion reduced infarct volume and oedema, blunted the hepatic acute phase response and neutrophil recruitment, and reduced blood-brain barrier leakage with upregulated tight junction proteins.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
