N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats.
RatOtherSprague-Dawleyn = 384 pups in vivo, 6 per time point per assay per group acro…intraperitoneal in vivo; direct addition to culture medium in vitro0.05 mg/kg/day intraperitoneal in vivo; 0.5 mM in vitro on…started on postnatal day 8, that is 4 days after cessation of hyperoxia exposur…
Model: hyperoxia (95% oxygen for 72 h)-induced chronic lung disease in newborn rats, bronchopulmonary dysplasia model
MK-801 initiated during the recovery phase after acute hyperoxic injury had resolved improved alveolarisation, improved dynamic lung compliance and reduced hydroxyproline and procollagen I expression compared with untreated hyperoxia-exposed rats. In vitro, MK-801 inhibited hyperoxia-induced upregu…
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