Preclinical evidence 4
4 studies reported at therapy level; 4 evidence entries itemised.
RatTBIFluid percussionLong-EvansMaleAcute post-traumatic period, within the 24 h following injury
Model: Lateral fluid percussion traumatic brain injury
Lateral fluid percussion injury increased c-fos and BDNF maximally 1-6 h after injury in the ipsilesional hippocampus and increased Bax bilaterally over the same window. MK801 attenuated the injury-induced increases in BDNF and Bax.
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RatIschaemia-reperfusionOther / unspecified
Model: Photothrombotic retinal vessel occlusion producing acute retinal ischaemia in vivo
Spreading depolarisation episodes were generated in the rat retina in vivo after photothrombotic vessel occlusion, propagating at 3.0 plus or minus 0.1 mm/min with a negative direct current shift, transient cessation of spiking, arteriole constriction and reduced tissue oxygen tension. Administrati…
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RatTBIUnspecifiedWistarIntraperitoneal1 mg/kg body weightImmediately after induction of traumatic injury
Model: Contusion traumatic brain injury in immature rat pups
A single 1 mg/kg intraperitoneal dose reduced trauma-induced hippocampal neuron loss, altered BDNF, NGF and NMDA receptor expression, and improved anxiety-related behaviour and hippocampus-dependent memory two months later.
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RatOtherSprague-Dawleyn = 384 pups in vivo, 6 per time point per assay per group acro…intraperitoneal in vivo; direct addition to culture medium in vitro0.05 mg/kg/day intraperitoneal in vivo; 0.5 mM in vitro on…started on postnatal day 8, that is 4 days after cessation of hyperoxia exposur…
Model: hyperoxia (95% oxygen for 72 h)-induced chronic lung disease in newborn rats, bronchopulmonary dysplasia model
MK-801 initiated during the recovery phase after acute hyperoxic injury had resolved improved alveolarisation, improved dynamic lung compliance and reduced hydroxyproline and procollagen I expression compared with untreated hyperoxia-exposed rats. In vitro, MK-801 inhibited hyperoxia-induced upregu…
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