Neurobiological Effects of Morphine after Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-Dawleymaleintravenousescalating dose, specific mg/kg not stated in abstractinitiated in the acute post-injury phase, across the first seven days post-inju…
Model: spinal contusion (T12) injury
Intravenous morphine after spinal contusion injury caused near-complete loss of NeuN positive neurons at the lesion, decreased astrocyte (GFAP) and microglial (OX-42) marker expression, attenuated locomotor recovery, decreased weight gain and induced opioid-induced hyperalgesia, indicating morphine…
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