Acceleration of Healing of Traumatic Tympanic Membrane Perforation in Rats by Implanted Collagen Membrane Integrated with Collagen-Binding Basic Fibroblast Growth Factor.
RatWoundSprague-DawleyLocal implantation at the perforation siteAt the time of perforation
Model: Acute traumatic tympanic membrane perforation
CBD-bFGF was released gradually from the collagen membrane and increased fibroblast proliferation in vitro. In rats the CBD-bFGF integrated membrane raised the early healing rate at about 7 days, shortened healing time and restored tympanic membrane structure and hearing.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.