THERAPY DOSSIER · th-c58f16f7e35c

Collagen membrane integrated with collagen-binding basic fibroblast growth factor (CBD-bFGF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04233892 ↗PHASE1/PHASE2unknown

Clinical Study of in Situ Regeneration of Endometrium

Infertility, Female, of Uterine Origin · Endometrial Fibrosis

Enrolment: 345 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27733103 ↗2016Reported benefit

Acceleration of Healing of Traumatic Tympanic Membrane Perforation in Rats by Implanted Collagen Membrane Integrated with Collagen-Binding Basic Fibroblast Growth Factor.

RatWoundSprague-DawleyLocal implantation at the perforation siteAt the time of perforation

Model: Acute traumatic tympanic membrane perforation

CBD-bFGF was released gradually from the collagen membrane and increased fibroblast proliferation in vitro. In rats the CBD-bFGF integrated membrane raised the early healing rate at about 7 days, shortened healing time and restored tympanic membrane structure and hearing.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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