Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats.
RatRadiationSprague-DawleyMalen = 72 rats for model establishment; 4 groups of 16 for growth…Subcutaneous injectionNanoparticle group, single 1 mL injection carrying 700 ng V…After irradiation, during the phase of developing skin injury
Model: Single 45 Gy dose of 4 MeV electron beam irradiation to a 45 by 40 mm field on the buttock skin at 600 cGy per minute
VEGF was more effective than bFGF or HGF at limiting apoptosis and delaying injury progression. A single injection of VEGF165-chitosan nanoparticles delayed hair loss and ulceration significantly more than a single injection of free VEGF165 (p less than 0.01), and matched or exceeded daily free VEG…
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