THERAPY DOSSIER · th-ff1b84dd2978

VEGF165 loaded in chitosan nanoparticles (ionic gelation with sodium tripolyphosphate), compared with free VEGF165, bFGF and HGF

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27727163 ↗2016Reported benefit

Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats.

RatRadiationSprague-DawleyMalen = 72 rats for model establishment; 4 groups of 16 for growth…Subcutaneous injectionNanoparticle group, single 1 mL injection carrying 700 ng V…After irradiation, during the phase of developing skin injury

Model: Single 45 Gy dose of 4 MeV electron beam irradiation to a 45 by 40 mm field on the buttock skin at 600 cGy per minute

VEGF was more effective than bFGF or HGF at limiting apoptosis and delaying injury progression. A single injection of VEGF165-chitosan nanoparticles delayed hair loss and ulceration significantly more than a single injection of free VEGF165 (p less than 0.01), and matched or exceeded daily free VEG…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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