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PEBBLE / ATLAS
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PRECLINICAL PUBLICATION · 2016

Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute gamma-Irradiation.

Rat / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 27704349 ↗2016Reported benefit

Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute gamma-Irradiation.

RatRadiationOutbredMaleInjection (route not specified)6 hours, 2 hours or 30 minutes before irradiation

Model: Single sublethal whole-body gamma-irradiation at 6 Gy

Injection of bone marrow total RNA 30 minutes before irradiation restored erythropoiesis most effectively, with a reticulocyte count at 5 days about 30-fold higher than saline controls. Injection at 2 hours or 30 minutes before irradiation significantly increased new erythroblastic islands in the b…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.