THERAPY DOSSIER · th-63fed1e5bed6

Total RNA from bone marrow of healthy donor rats

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27704349 ↗2016Reported benefit

Effect of Preliminary Injection of Bone Marrow Cell Total RNA on Erythropoiesis Recovery Dynamics in Rats Exposed to an Acute gamma-Irradiation.

RatRadiationOutbredMaleInjection (route not specified)6 hours, 2 hours or 30 minutes before irradiation

Model: Single sublethal whole-body gamma-irradiation at 6 Gy

Injection of bone marrow total RNA 30 minutes before irradiation restored erythropoiesis most effectively, with a reticulocyte count at 5 days about 30-fold higher than saline controls. Injection at 2 hours or 30 minutes before irradiation significantly increased new erythroblastic islands in the b…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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