Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.
MouseChemical/toxinC57BL/6, including G-CSF knockout miceNeutrophil depletion by Ly6G antibody injection around the time of acid instill…
Model: Unilateral acid instillation producing severe but survivable acute lung injury with features of the acute respiratory distress syndrome
Neutrophil depletion with Ly6G antibody impaired type II pneumocyte proliferation and re-epithelialisation and increased alveolar protein concentration. Neutropenic G-CSF knockout mice showed the same defective repair, which was reversed by administration of exogenous G-CSF, indicating that neutrop…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.