Chronic administration of [Pyr] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats.
RatSpinal cord injuryCompressionWistarMaleIntrathecal injection1 microgram and 5 micrograms per injectionStarted on day 1 after spinal cord injury
Model: Compression spinal cord injury induced with an aneurysm clip after laminectomy at the T6 to T8 level
Both 1 microgram and 5 microgram doses improved locomotor activity and reduced pain symptoms, cavity size and caspase-3 levels, with benefits sustained over the 8-week follow-up.
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