Apelin as Potential Treatment for CKD (AlPaCKa; [Pyr]apelin-13)
Chronic Kidney Diseases · Cardiovascular Diseases · Endothelial Dysfunction
Enrolment: 46 · Results not recorded
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Hormone · ChEMBL record is the generic peptide APELIN (molecule_type Unknown, structure_type NONE, max_phase 2); it is NOT specific to the [Pyr1]apelin-13 isoform. get_mechanism was NOT called for this record within the run time budget, so moa_list is empty by omission rather than by a negative result.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Kidney Diseases · Cardiovascular Diseases · Endothelial Dysfunction
Enrolment: 46 · Results not recorded
Cardiovascular Disease
Enrolment: 52 · Results not recorded
Pulmonary Arterial Hypertension · Heart Failure
Enrolment: 63 · Results not recorded
Heart Disease · Heart Failure · Vasodilatation
Enrolment: 12 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Compression spinal cord injury induced with an aneurysm clip after laminectomy at the T6 to T8 level
Both 1 microgram and 5 microgram doses improved locomotor activity and reduced pain symptoms, cavity size and caspase-3 levels, with benefits sustained over the 8-week follow-up.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.