Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs.
RatRadiationWAG/RijCmcrFemalen = 30 rats in the 12.5 Gy experiment (n=10 per irradiated grou…Oral (drinking water) for lisinopril and enrofloxacin; subcutaneous injection for saline and G-CSFLisinopril approximately 24 mg per m2 per day delivered in…Lisinopril started 7 days after irradiation; enrofloxacin from day 2; saline hy…
Model: Partial-body irradiation with one hind leg shielded (leg-out PBI), single doses of 11 to 13.5 Gy delivered by XRAD 320 kVp orthovoltage x-ray at 1.75 Gy per minute; shielded leg received 2 Gy
After 12.5 Gy leg-out PBI, 9 of 10 untreated rats were morbid by 150 days whereas all lisinopril-treated rats survived with blood urea nitrogen below 55 mg/dL. Saline plus enrofloxacin reduced 30-day morbidity after 13 Gy (p<0.01), and adding lisinopril mitigated overall morbidity to beyond 150 day…
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