Phenytoin accelerates tendon healing in a rat model of Achilles tendon rupture.
RatOtherWistarMalen = 30 rats divided into 3 groupsIntraperitoneal100 mg/kgStarted after tendon injury and continued for 21 days
Model: Surgical Achilles tendon rupture
Tendon healing was significantly better in the phenytoin group than in the injured control group on day 21 (p<0.05), with increased fibroblast numbers, fibrillar collagen synthesis and vascularity and suppressed inflammation.
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