4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis.
RatChemical/toxinSprague-Dawley (SPF)Malen = 24 rats, 8 per group across three groupsIntraperitoneal injection50 mg/kg per dayProphylactic, given for 3 days before induction of pancreatitis, with severe ac…
Model: Severe acute pancreatitis induced by standardised retrograde infusion of 5% sodium taurocholate saline solution, 1 mL/kg body weight, into the biliopancreatic duct at 0.1 mL/min after laparotomy
4-PBA pretreatment significantly reduced pancreatic histopathological score, serum TNF-alpha, IL-1 beta and insulin, raised serum glucose, reduced islet expression of BiP, ORP150, CHOP and caspase-3, increased islet insulin staining, and ameliorated beta-cell ultrastructural damage (all p<0.05). Re…
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