Tranexamic Acid Attenuates The Loss of Lung Barrier Function in a Rat Model of Polytrauma And Hemorrhage With Resuscitation.
RatHaemorrhage/shockControlledSprague-DawleyMaleBolus injection prior to fresh whole blood resuscitation (route not stated beyond bolus administration)10 mg/kg in 0.2 mLResuscitation begun 1 h after completion of polytrauma and haemorrhage, with tr…
Model: Polytrauma (laparotomy with trauma to intestines, liver and right leg skeletal muscle, plus right femur fracture) followed by controlled haemorrhage of 40% blood volume and resuscitation
Polytrauma with haemorrhage and fresh whole blood resuscitation raised lung water content, which was significantly reduced by added tranexamic acid. Tranexamic acid further reduced lung neutrophil and monocyte counts, neutrophil elastase and complement C5a beyond fresh whole blood alone. Lung plasm…
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