Protection Provided by a Gabexate Mesylate Thermo-SensitiveGel for Rats with Grade III Pancreatic Trauma.
RatOtherSprague-DawleyMalen = 42 rats: control n=6, pancreatic trauma n=18 (6 per time po…Direct injection into the body and head of the pancreasGel containing 0.1% (w/v) gabexate mesylate injected at 0.3…Immediately after creation of the grade III pancreatic injury
Model: Grade III pancreatic trauma, a 0.6 cm laceration with main pancreatic duct rupture created with hemostatic scissors adjacent to the duodenum via midline laparotomy
Gel treatment reduced ascites volume at every time point (2.42 plus or minus 1.24 mL vs 7.92 plus or minus 2.13 mL at 1 h; 4.88 plus or minus 1.29 vs 14.58 plus or minus 1.77 mL at 6 h; 6.17 plus or minus 2.52 vs 18.42 plus or minus 2.75 mL at 24 h, p<0.01). Serum amylase, lipase, C-reactive protei…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.