Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-kappaB signaling pathway.
RatOtherSprague-DawleyMalen = 40 rats divided into four groups (normal control, hypobaric…Given preventatively before hypobaric hypoxia exposure
Model: Hypobaric hypoxia exposure causing acute lung and cerebral injury
Puerarin reduced hypobaric hypoxia-induced lung and cerebral tissue injury on histopathology and improved Morris water maze performance. Bronchoalveolar lavage inflammatory cytokines fell in both preventative groups. Aquaporin 1 and aquaporin 4 were raised by hypobaric hypoxia and downregulated by…
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