Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
RatSpinal cord injuryComplete transectionSprague-DawleyMalen = n = 6 to 8 per group across experiments; total not statedIntrathecal (lumbar catheter, followed by a 20 microlitre saline flush)Bicuculline 0.3 microgram; gabazine 0.001 and 0.01 microgra…Approximately 24 h after transection or sham surgery; drug given 15 min before…
Model: Complete thoracic (T2) spinal cord transection with intrathecal cannulation; nociceptive sensitisation induced by 900 leg shocks, intrathecal lipopolysaccharide 100 microgram, or intradermal 3% capsaicin in 50 microlitre to the hindpaw
After transection GABA-A blockade became antinociceptive, with bicuculline and gabazine blocking shock-, lipopolysaccharide- and capsaicin-induced enhanced mechanical reactivity in injured rats but inducing it in intact rats; transection reduced membrane KCC2 by 42%, intrathecal DIOA in intact rats…
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