Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts (DART-HA)
Heart Failure, Congestive
Enrolment: 80 · Results not recorded
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Drug · Loop diuretic; inhibits the Na-K-2Cl cotransporter NKCC2 (INHIBITOR, direct interaction, disease efficacy true). Indexed on bumetanide, the lead agent of this combination. Bicuculline, gabazine and DIOA are research-grade pharmacological tools without therapeutic ChEMBL drug records; muscimol exists separately as CHEMBL273481 (max_phase 1). Black box warning present.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Heart Failure, Congestive
Enrolment: 80 · Results not recorded
Chronic Kidney Disease · Hypertension
Enrolment: 49 · Results not recorded
Autism Spectrum Disorder
Enrolment: 66 · Results not recorded
Heart Failure
Enrolment: 75 · Results not recorded
Type 2 Diabetes Mellitus
Enrolment: 42 · Results not recorded
Acute Decompensated Heart Failure
Enrolment: 4 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Complete thoracic (T2) spinal cord transection with intrathecal cannulation; nociceptive sensitisation induced by 900 leg shocks, intrathecal lipopolysaccharide 100 microgram, or intradermal 3% capsaicin in 50 microlitre to the hindpaw
After transection GABA-A blockade became antinociceptive, with bicuculline and gabazine blocking shock-, lipopolysaccharide- and capsaicin-induced enhanced mechanical reactivity in injured rats but inducing it in intact rats; transection reduced membrane KCC2 by 42%, intrathecal DIOA in intact rats…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Isolated in situ perfused mouse lung with main pulmonary artery and left atrium cannulated and perfusate of 1 mL blood plus 9 mL physiological solution; 120 min ischaemia with no ventilation or perfusion followed by 60 min reperfusion
In wild-type mice, ischaemia-reperfusion caused oedema (wet/dry 6.30 plus or minus 0.36), hyperpermeability (0.29 plus or minus 0.04), neutrophil sequestration (255.0 plus or minus 55.8 cells per high-power field) and nuclear factor-kappa B activation. Injury was more severe in WNK4 knockin and att…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.