Captopril pretreatment protects the lung against severe acute pancreatitis induced injury via inhibiting angiotensin II production and suppressing Rho/ROCK pathway.
RatChemical/toxinSprague-DawleyMalen = n = 30 per group; 90 rats in totalIntragastric5 mg/kg (approximately 0.4 mL)1 h before induction of severe acute pancreatitis
Model: Severe acute pancreatitis with associated lung injury induced by retrograde bile-pancreatic duct infusion of 5% sodium taurocholate at 0.1 mL per 100 g
Captopril pretreatment reduced pancreatic (9.1 to 5.8) and lung (3.7 to 2.6) histology scores, lung wet-to-dry ratio (5.74 to 4.25), Evans Blue extravasation, serum amylase (5695.7 to 3862.1 U/L) and lung angiotensin II (287.16 to 211.14 pg/mL), with lower AT1, RhoA, ROCK2 and MLCK expression but n…
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