Effects of early surgical decompression on functional and histological outcomes after severe experimental thoracic spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 64 adult female rats across treatment and control groups24 h after injury
Model: Severe thoracic spinal cord contusion injury (200 kilodynes)
No treatment group showed motor recovery beyond injured controls; durotomy and laminectomy produced neuropathic pain and durotomy increased lesion volume, whereas 3-level duraplasty increased white matter sparing without functional benefit and DuraSeal expansion compressed the cord in some animals.
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