THERAPY DOSSIER · th-fb1c0c1d6918

Decompressive laminectomy, durotomy and duraplasty with DuraSeal hydrogel dural sealant

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00000411 ↗PHASE4completed

Spine Patient Outcomes Research Trial (SPORT): Decompressive Laminectomy for Spinal Stenosis

Spinal Stenosis

Enrolment: 289 · Results not recorded

NCT02254590 ↗NAcompleted

Irrigation Endoscopic Decompressive Laminotomy for Spinal Stenosis Decompression

Lumbar Spinal Canal Stenosis

Enrolment: 104 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27636866 ↗2016Mixed findings

Effects of early surgical decompression on functional and histological outcomes after severe experimental thoracic spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemalen = 64 adult female rats across treatment and control groups24 h after injury

Model: Severe thoracic spinal cord contusion injury (200 kilodynes)

No treatment group showed motor recovery beyond injured controls; durotomy and laminectomy produced neuropathic pain and durotomy increased lesion volume, whereas 3-level duraplasty increased white matter sparing without functional benefit and DuraSeal expansion compressed the cord in some animals.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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