Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)ICRmaleintravenous50 and 100 microgram/kg2 hours after MCAO
Model: middle cerebral artery occlusion and reperfusion-induced ischaemic stroke
Salvianolic acid A at 50 and 100 microgram/kg intravenously given 2 h after MCAO enhanced survival, improved moving activity and reduced brain infarction and apoptosis by limiting blood-brain barrier breakdown, nitrosative stress and NF-kB p65 and p25/Cdk5 activation, and promoted neurogenesis prot…
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