Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1.
RatBurnUnspecifiedSprague-DawleyMalen = n = 8 per group across five groupsIntraperitonealFirst dose immediately after the burn
Model: Full-thickness dermal burn covering 40% total body surface area produced by immersing the shaved back in 98 degrees C water for 15 s, with lactated Ringer resuscitation
Melatonin reduced burn-induced glomerular necrosis and tubular casts, lowered serum creatinine and blood urea nitrogen, cut malondialdehyde while restoring superoxide dismutase and glutathione, reduced TNF-alpha, IL-1beta and ICAM-1 and raised IL-10, lowered Bax, cleaved caspase-3 and TUNEL apoptos…
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