Effects of acetaminophen and mannitol on crush injuries in rats: An experimental study.
RatCrushLimb / muscle crushSprague-DawleyMalen = 36 rats in six groups of sixIntraperitonealAcetaminophen 100 mg/kg; mannitol 1 g/kg
Model: Crush injury produced by compression of the gastrocnemius muscle region for 2 or 24 hours
No significant differences in sodium, potassium, alanine aminotransferase or creatinine clearance between treatment groups, but acetaminophen reduced histopathological renal damage more than mannitol, with the combination intermediate.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.