Macrophage polarization and MRSA infection in burned mice.
MouseBurnUnspecifiedNOD scid gamma (NSG) and other burned mouse strainsGiven both before infection and therapeutically after methicillin-resistant Sta…
Model: Thermal burn of 5%, 15% or 25% total body surface area followed by methicillin-resistant Staphylococcus aureus infection in the sub-acute phase
All mice with 25% total body surface area burn treated with CCL1 antisense oligodeoxynucleotide survived methicillin-resistant Staphylococcus aureus infection whereas all untreated mice died within 4 days, with recovery of M1 macrophages and control of sepsis when the oligodeoxynucleotide was given…
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