Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyIntravenous infusion10 weeks after injury
Model: Severe contusive spinal cord injury studied in the chronic phase
Intravenous mesenchymal stem cells given 10 weeks after severe contusion improved motor recovery, reduced blood spinal cord barrier leakage, increased microvasculature and produced extensive remyelination with increased corticospinal and serotonergic fibre sprouting.
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