Autologous Bone Marrow-derived MSC Versus Tension-free Vaginal Tape for Female Stress Urinary Incontinence
Urinary Incontinence, Stress
Enrolment: 50 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Urinary Incontinence, Stress
Enrolment: 50 · Results not recorded
Multiple Sclerosis
Enrolment: 2 · Results not recorded
Myocardial Infarction
Enrolment: 20 · Results not recorded
Type 2 Diabetes Mellitus
Enrolment: 60 · Results not recorded
Ileal Pouch · Crohn Disease
Enrolment: 24 · Results not recorded
Premature Ovarian Failure
Enrolment: 50 · Results not recorded
Leg Length Inequality
Enrolment: 6 · Results not recorded
Ulcerative Colitis · Inflammatory Bowel Diseases
Enrolment: 4 · Results not recorded
Asthma
Enrolment: 3 · Results not recorded
Ankle Osteoarthritis
Enrolment: 40 · Results not recorded
6 studies reported at therapy level; 6 evidence entries itemised.
Model: Severe contusive spinal cord injury studied in the chronic phase
Intravenous mesenchymal stem cells given 10 weeks after severe contusion improved motor recovery, reduced blood spinal cord barrier leakage, increased microvasculature and produced extensive remyelination with increased corticospinal and serotonergic fibre sprouting.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Permanent focal cerebral infarction by bipolar coagulation of the left middle cerebral artery, producing secondary acute lung injury
Transplanted cells survived and distributed widely in lung. At 7 days the wet-to-dry weight ratio fell, arterial oxygen tension rose and carbon dioxide tension fell relative to brain ischaemia alone (all P<0.05), with reduced TNF-alpha mRNA and protein at 3 and 7 days and fewer inflammatory cells.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Unilateral lung contusion plus chronic restraint stress (2 h restraint on days 1 to 6 after contusion)
Lung injury score fell from 4.4 (2.2) with contusion plus chronic stress to 1.7 (0.8) with mesenchymal stem cells, with an inflammatory cell subscore of zero, and regulatory T cells rose from 6.2% (1.3) to 12.9% (2.4).
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute brain trauma using a controlled cortical impact injury device
Stem cell treated rats showed earlier and more widespread increases in cerebral 18F-FDG uptake, including right parietal and primary somatosensory cortex, than untreated trauma controls.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Thermal comb burn model on the back, assessing the zone of stasis
Apoptosis counts were significantly lower and the scintigraphic percentage of vital tissue in the stasis zone significantly higher in mesenchymal stem cell-treated rats than in saline controls. Systemic cytokine levels did not differ significantly between the groups.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Subdermal implantation of a porous titanium percutaneous implant on the dorsum, creating a skin wound
Collagen infiltrating the porous coating was significantly greater with treated implants at 3 and 28 days, with earlier influx and resolution of inflammatory infiltrate. Vascularisation increased over time in both groups without a significant difference, and epidermal downgrowth was minimal in all…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.