The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats.
RatSpinal cord injuryContusionSprague-DawleyMale
Model: Acute spinal cord injury induced by a modified Allen's weight-drop method
Puerarin increased Basso-Beattie-Bresnahan score, attenuated histological injury, reduced neuronal loss, inhibited glial activation, lowered inflammation and apoptosis, and restored downregulated PI3K and phospho-Akt expression.
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