Neuroprotective actions of pterostilbene on hypoxic-ischemic brain damage in neonatal rats through upregulation of heme oxygenase-1.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Before induction of hypoxic-ischaemic injury (pretreatment)
Model: Neonatal hypoxic-ischaemic brain damage in postnatal day 7 rat pups
Pterostilbene pretreatment reduced infarct volume, brain oedema and neurological score and improved motor coordination and working memory, with lower proinflammatory cytokines, less programmed cell death and reduced oxidative stress, all reversed by the heme oxygenase-1 inhibitor zinc protoporphyri…
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