In vivo protective effect of phosphatidylcholine on carbon tetrachloride induced nephrotoxicity.
MouseChemical/toxinICRMaleOral100 mg/kg in 0.1 mL corn oilCo-administered with carbon tetrachloride exposure
Model: Carbon tetrachloride-induced nephrotoxicity; carbon tetrachloride in corn oil 0.1 mL at 1.2 g/kg injected intraperitoneally twice a week
Phosphatidylcholine co-treatment significantly lowered blood urea nitrogen and creatinine at 7 days, abrogated carbon tetrachloride-induced histopathological injury and fibrosis, reduced oxidative damage markers and counteracted the downregulation of aquaporin-1.
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