Effect of Choline Supplemented as Phosphatidylcholine on Post-Methionine Loading and Fasting Concentrations of Plasma Homocysteine in Healthy Volunteers
Healthy · Cardiovascular Diseases
Enrolment: 26 · Results not recorded
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Nutraceutical · No mechanism-of-action record in ChEMBL for this substance-level entry. Matched on the ChEMBL synonym 'Phospholipids egg'; ChEMBL max_phase 3, no first-approval date recorded. The related approved entity dipalmitoylphosphatidylcholine (colfosceril palmitate, CHEMBL1200737, approved 1990) is a distinct pulmonary surfactant product and was not used as the match.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy · Cardiovascular Diseases
Enrolment: 26 · Results not recorded
Multiple Sclerosis, Relapsing-Remitting
Enrolment: 162 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Carbon tetrachloride-induced nephrotoxicity; carbon tetrachloride in corn oil 0.1 mL at 1.2 g/kg injected intraperitoneally twice a week
Phosphatidylcholine co-treatment significantly lowered blood urea nitrogen and creatinine at 7 days, abrogated carbon tetrachloride-induced histopathological injury and fibrosis, reduced oxidative damage markers and counteracted the downregulation of aquaporin-1.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.