Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice.
MouseChemical/toxinSwiss albinoMalen = Three groups of 10 male mice; 30 in total500 mg/kg body weightCo-administered with gentamicin
Model: Gentamicin-induced acute renal toxicity; gentamicin 80 mg/kg body weight administered orally for 7 days
Co-administration of propolis with gentamicin lowered blood urea nitrogen, restored healthy glomeruli with normal cellularity, reduced tubular injury, collagen and reticular fibre deposition, and decreased apoptosis, kidney injury and oxidative stress markers.
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