FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-kB in Microglia Cells
RatSpinal cord injuryContusionSprague-DawleyMale
Model: Acute spinal cord contusion injury in adult rats, plus hypoxia-treated primary spinal cord microglia cultures
FK-506 reversed the rise in TNF-alpha, IL-1beta and IL-6 and the increased NF-kB activation seen 3 days after contusion, without altering microglial number.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.