PRECLINICAL PUBLICATION · 2016

Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Mesenchymal stem cells (bone marrow derived or aortic vascular wall resident); comparator SOD mimetic EUK134

PMID 27572073 ↗2016Reported benefit

Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression

MouseRadiationAdoptive transferEarly phase after irradiation

Model: Whole thorax irradiation mouse model of radiation-induced pneumopathy

Adoptive transfer of bone marrow or vascular wall derived MSCs shortly after whole thorax irradiation limited endothelial cell loss and fibrosis progression and restored SOD1 levels.

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.