Nafamostat Mesilate Attenuates Ischemia-Reperfusion-Induced Renal Injury
MouseIschaemia-reperfusionRenalC57BL/6Malen = Four groups of C57BL/6 mice; group sizes not stated2 mg/kg
Model: Renal ischaemia-reperfusion injury by clamping of both renal artery and vein, reperfusion 27 minutes after clamping; kidneys harvested 24 hours after injury. In vitro HK-2 cells subjected to 6 hours hypoxic injury under mineral paraffin oil
Nafamostat mesilate lowered blood urea nitrogen, serum creatinine and renal injury scores, reduced apoptosis markers and nitric oxide synthase expression, and improved survival of hypoxic HK-2 cells.
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