Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy
Acute Kidney Injury
Enrolment: 60 · Results not recorded
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Drug · No ChEMBL mechanism-of-action table record. USAN stem '-stat (-amostat)' = proteolytic enzyme inhibitor; used clinically as a broad serine protease inhibitor anticoagulant. Mesylate salt is CHEMBL3989553 (parent CHEMBL273264).
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Kidney Injury
Enrolment: 60 · Results not recorded
Acute Kidney Injury
Enrolment: 66 · Results not recorded
COVID-19
Enrolment: 59 · Results not recorded
COVID-19
Enrolment: 104 · Results not recorded
COVID-19
Enrolment: 13 · Results not recorded
Critical Illness · Anticoagulation
Enrolment: 40 · Results not recorded
Pharmacokinetics · Healthy Volunteer
Enrolment: 54 · Results not recorded
Pharmacokinetics
Enrolment: 111 · Results not recorded
ECMO
Enrolment: 140 · Results not recorded
Extracorporeal Membrane Oxygenation Complication
Enrolment: 80 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Renal ischaemia-reperfusion injury by clamping of both renal artery and vein, reperfusion 27 minutes after clamping; kidneys harvested 24 hours after injury. In vitro HK-2 cells subjected to 6 hours hypoxic injury under mineral paraffin oil
Nafamostat mesilate lowered blood urea nitrogen, serum creatinine and renal injury scores, reduced apoptosis markers and nitric oxide synthase expression, and improved survival of hypoxic HK-2 cells.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Transient middle cerebral artery occlusion with reperfusion
Nafamostat mesilate significantly decreased infarct size and brain oedema, attenuated neuronal degeneration and glial activation, and reduced expression of the endoplasmic reticulum stress markers GRP78, CHOP and phosphorylated eIF2alpha.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.