Hepatoprotective effect of apple polyphenols against concanavalin A-induced immunological liver injury in mice
MouseChemical/toxinMalePretreatment, daily for seven days before concanavalin A challenge
Model: Concanavalin A-induced immunological liver injury, single intravenous administration of concanavalin A
Apple polyphenol pretreatment normalised serum transaminases and protein indices, improved liver histopathology, lowered TNF-alpha, IFN-gamma and nitric oxide, and restored MDA, SOD and GSH.
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