Inhaled sulfur dioxide causes pulmonary and systemic inflammation leading to fibrotic respiratory disease in a rat model of chemical-induced lung injury.
RatChemical/toxinSprague-Dawleyfemale1 hour after sulfur dioxide exposure
Model: single inhalation exposure to 2200 ppm sulfur dioxide for 10 minutes, chemical-induced acute lung injury
A single dose of dexamethasone given 1 h after sulfur dioxide inhalation significantly counteracted the acute inflammatory response but gave only partial protection against airway hyperresponsiveness and did not prevent long-term pulmonary fibrosis and collagen deposition.
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