Effects of Platelet-Rich Plasma (PRP) on a Model of Renal Ischemia-Reperfusion in Rats
RatIschaemia-reperfusionRenalSprague-DawleyMalen = 45 rats randomised into 3 groups of 15 (blood donors, PRP,…Subcapsular renal injection via five punctures (anterior, posterior, lateral, upper pole, lower pole)1 mL of activated PRP distributed over the renal surfaceExactly 30 minutes into the 45 minute ischaemic clamp
Model: Monorenal rats after right nephrectomy, left renal pedicle clamped for 45 minutes with a microaneurysm clamp under 2 per cent isoflurane; seven days of reperfusion before euthanasia
Subcapsular PRP given during ischaemia worsened outcome, with higher histological damage scores (13 versus 7, p less than 0.001), higher percentage vesicles (54 versus 26, p equals 0.001) and lower renal artery maximum velocity (73.08 plus or minus 20.31 versus 87.1 plus or minus 14.15 cm/s, p equa…
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