THERAPY DOSSIER · th-cb2f6f4e7bc6

Allogeneic platelet-rich plasma activated with 10 per cent calcium chloride (0.8 mL PRP plus 0.2 mL CaCl2), mean 1,282,000 plus or minus 363,000 platelets per microlitre, classified P4-x-Bbeta

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06680856 ↗PHASE1/PHASE2completed

Phase II, Multicenter, Double Blind, Randomized Controlled Trial on 'Off the Shelf' Allogeneic Platelet Rich Plasma (PRP) to Treat Diabetic Foot Ulcers

Diabetic Foot Ulcer · Skin Lesions · Allogeneic · PRP

Enrolment: 72 · Results not recorded

NCT02019537 ↗NAcompleted

Allogeneic Platelet-Rich Plasma Versus Corticosteroid Injection for the Treatment of Rotator Cuff Disease: A Randomized Controlled Trial

Shoulder Impingement Syndrome

Enrolment: 60 · Results not recorded

NCT01458691 ↗NAcompleted

Intra-articular Injection of Allogeneic PRP for Adhesive Capsulitis

Adhesive Capsulitis

Enrolment: 58 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27551718 ↗2016Reported harm

Effects of Platelet-Rich Plasma (PRP) on a Model of Renal Ischemia-Reperfusion in Rats

RatIschaemia-reperfusionRenalSprague-DawleyMalen = 45 rats randomised into 3 groups of 15 (blood donors, PRP,…Subcapsular renal injection via five punctures (anterior, posterior, lateral, upper pole, lower pole)1 mL of activated PRP distributed over the renal surfaceExactly 30 minutes into the 45 minute ischaemic clamp

Model: Monorenal rats after right nephrectomy, left renal pedicle clamped for 45 minutes with a microaneurysm clamp under 2 per cent isoflurane; seven days of reperfusion before euthanasia

Subcapsular PRP given during ischaemia worsened outcome, with higher histological damage scores (13 versus 7, p less than 0.001), higher percentage vesicles (54 versus 26, p equals 0.001) and lower renal artery maximum velocity (73.08 plus or minus 20.31 versus 87.1 plus or minus 14.15 cm/s, p equa…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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